Identity Crisis: It’s Not Just Foxp3 Anymore

What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity.

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 37; no. 5; pp. 759 - 761
Main Authors Delgoffe, Greg M., Bettini, Matthew L., Vignali, Dario A.A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.11.2012
Elsevier Limited
Subjects
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Gene expression
Rodents
T cell receptors
Transcription factors
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Summary:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2012.10.012