Percutaneous microwave ablation for HCV-related hepatocellular carcinoma: Efficacy, safety, and survival

• Published in: The Turkish journal of gastroenterology Vol. 30; no. 5; pp. 445 - 453
• Main Authors: Darweesh, Samar K, Gad, Amal A
• Format: Journal Article
• Language: English
• Published: Turkey AVES 01.05.2019; Turkish Society of Gastroenterology
• Subjects: Ablation (Surgery); Burns; Cancer; Carcinoma; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - surgery; Carcinoma, Hepatocellular - virology; Care and treatment; Catheter Ablation - methods; Catheter Ablation - mortality; Development and progression; Female; Health aspects; Hepacivirus; Hepatitis C - complications; Hepatitis C - virology; Hepatitis C virus; Hepatocellular carcinoma; Hospital patients; Humans; Liver; Liver diseases; Liver Neoplasms - surgery; Liver Neoplasms - virology; Male; Medical research; Microwaves - therapeutic use; Middle Aged; Original; Prognosis; Recurrence (Disease); Skin; Survival Rate; Thrombosis; Treatment Outcome; Tumors
• ISSN: 1300-4948; 2148-5607
• DOI: 10.5152/tjg.2019.17191

Hepatocellular carcinoma (HCC) has a poor prognosis if managed late. Percutaneous microwave ablation (MWA) emerged as one of the top therapeutic decisions for non-surgical patients. The aim of the present study aim was to evaluate the efficacy, side effects, and survival after MWA of hepatitis C virus (HCV)-related HCC tumors with spectrum sizes up to 5 cm. Fifty-nine patients with early HCC were treated in the Hepatology Department using percutaneous MWA. Patients were assessed for side effects and efficacy that includes the rate of complete ablation, primary or de novo recurrence, and survival. Complete ablation was achieved in 57 (96.6%) patients treated by MWA, with a minor complication rate of 3.3% (n=2) including liver abscess formation and abdominal skin burn. The ablation rates in lesions <3 versus 3-5 cm were not different. Of the patients, 3 (5%) had primary recurrence in the treated HCC tumors, de novo lesions (secondary recurrence) developed in 8 (13.5%, 5 of them >3 cm), and 2 (3.3%) had malignant portal vein thrombosis. The survival rates were 95.4% and 69% at 1 and 2 years, respectively. Percutaneous MWA had achieved a safe and effective treatment with good overall survival in patients with HCV-related HCC.