Enzyme Activities of Liver Plasma Membrane in Rat Bile after the Intrabiliary Retrograde Infusion of Triton X-100

The activities of three bile canalicular enzymes, alkaline phosphatase, 5'-nucleotidase and ATPase, and protein concentration in bile were significantly elevated by the intrabiliary retrograde infusion of Triton X-100. The results suggest that a part of the bile canalicular site of the liver pl...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 25; no. 6; pp. 1447 - 1449
Main Authors NAKAE, HIROKO, SHIOMI, YASUKO, MURANISHI, SHOZO
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1977
Japan Science and Technology Agency
Subjects
alkaline phosphatase
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Summary:The activities of three bile canalicular enzymes, alkaline phosphatase, 5'-nucleotidase and ATPase, and protein concentration in bile were significantly elevated by the intrabiliary retrograde infusion of Triton X-100. The results suggest that a part of the bile canalicular site of the liver plasma membrane was solubilized by the treatment. This explains the fact that the active biliary excretion of organic anions and cations was markedly inhibited by the same treatment.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.25.1447