Strategies to design clinical studies to identify predictive biomarkers in cancer research

Highlights • Predictive biomarkers are essential to improve the efficacy of anticancer drugs. • Biomarker identification requires well-designed studies that follow an adequate methodology. • This manuscript provides a methodological framework to design biomarker identificaton studies based on previo...

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Published inCancer treatment reviews Vol. 53; pp. 79 - 97
Main Authors Perez-Gracia, Jose Luis, Sanmamed, Miguel F, Bosch, Ana, Patiño-Garcia, Ana, Schalper, Kurt A, Segura, Victor, Bellmunt, Joaquim, Tabernero, Josep, Sweeney, Christopher J, Choueiri, Toni K, Martín, Miguel, Fusco, Juan Pablo, Rodriguez-Ruiz, Maria Esperanza, Calvo, Alfonso, Prior, Celia, Paz-Ares, Luis, Pio, Ruben, Gonzalez-Billalabeitia, Enrique, Gonzalez Hernandez, Alvaro, Páez, David, Piulats, Jose María, Gurpide, Alfonso, Andueza, Mapi, de Velasco, Guillermo, Pazo, Roberto, Grande, Enrique, Nicolas, Pilar, Abad-Santos, Francisco, Garcia-Donas, Jesus, Castellano, Daniel, Pajares, María J, Suarez, Cristina, Colomer, Ramon, Montuenga, Luis M, Melero, Ignacio
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.02.2017
Subjects
Biomarkers
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biomedical Research - methods
Biomedical Research - standards
Cancer and Oncology
Cancer och onkologi
Clinical Medicine
Clinical Studies as Topic
Clinical trial design
Clinical Trials as Topic
Extreme phenotypes
Hematology, Oncology and Palliative Medicine
Humans
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Mutation
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins c-kit - genetics
ras Proteins - genetics
Rearrangement
Receptor Protein-Tyrosine Kinases - genetics
Receptor, Epidermal Growth Factor - genetics
Receptor, ErbB-2 - analysis
Biomarkers
Extreme phenotypes
Clinical trial design
Mutation
Rearrangement
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Summary:Highlights • Predictive biomarkers are essential to improve the efficacy of anticancer drugs. • Biomarker identification requires well-designed studies that follow an adequate methodology. • This manuscript provides a methodological framework to design biomarker identificaton studies based on previous successful experiences.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2016.12.005