miR-9: a versatile regulator of neurogenesis
Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balanci...
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Published in | Frontiers in cellular neuroscience Vol. 7; p. 220 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
20.11.2013
Frontiers Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in embryonic neural progenitor populations. Key transcriptional regulators such as FoxG1, Hes1 or Tlx, were identified as direct targets of miR-9, placing it at the core of the gene network controlling the progenitor state. Recent data also suggest that this function could extend to adult neural stem cells. Other studies point to a role of miR-9 in differentiated neurons. Moreover miR-9 has been implicated in human brain pathologies, either displaying a protective role, such as in Progeria, or participating in disease progression in brain cancers. Altogether functional studies highlight a prominent feature of this highly conserved microRNA, its functional versatility, both along its evolutionary history and across cellular contexts. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 PMCID: PMC3834235 Reviewed by: Alessandro Cellerino, Scuola Normale Superiore, Italy; Federico Cremisi, Scuola Normale Superiore di Pisa, Italy This article was submitted to the journal Frontiers in Cellular Neuroscience. Edited by: Alessandro Cellerino, Scuola Normale Superiore, Italy |
ISSN: | 1662-5102 1662-5102 |
DOI: | 10.3389/fncel.2013.00220 |