Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study

Polycaprolactone (PCL) is widely used in tissue engineering due to its interesting properties, namely biocompatibility, biodegradability, elastic nature, availability, cost efficacy, and the approval of health authorities such as the American Food and Drug Administration (FDA). The PCL degradation r...

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Published inPolymers Vol. 14; no. 16; p. 3397
Main Authors Dias, Juliana R., Sousa, Aureliana, Augusto, Ana, Bártolo, Paulo J., Granja, Pedro L.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2022
MDPI
Subjects
Biocompatibility
Biodegradability
Chromatography
Contact angle
Degradation
Drug approval
electrospinning nanofibers
enzymatic
Enzymes
hydrolytic
in vitro
In vivo methods and tests
Mechanical properties
Molecular weight
Morphology
Polycaprolactone
Scanning electron microscopy
Tissue engineering
Wound healing
United Kingdom
Portugal
Missouri
St Louis Missouri
United Kingdom > UK
United States > US
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Summary:Polycaprolactone (PCL) is widely used in tissue engineering due to its interesting properties, namely biocompatibility, biodegradability, elastic nature, availability, cost efficacy, and the approval of health authorities such as the American Food and Drug Administration (FDA). The PCL degradation rate is not the most adequate for specific applications such as skin regeneration due to the hydrophobic nature of bulk PCL. However, PCL electrospun fiber meshes, due to their low diameters resulting in high surface area, are expected to exhibit a fast degradation rate. In this work, in vitro and in vivo degradation studies were performed over 90 days to evaluate the potential of electrospun PCL as a wound dressing. Enzymatic and hydrolytic degradation studies in vitro, performed in a static medium, demonstrated the influence of lipase, which promoted a rate of degradation of 97% for PCL meshes. In an in vivo scenario, the degradation was slower, although the samples were not rejected, and were well-integrated in the surrounding tissues inside the subcutaneous pockets specifically created.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym14163397