Long non-coding RNAs involved in autophagy regulation

• Published in: Cell death & disease Vol. 8; no. 10; p. e3073
• Main Authors: Yang, Lixian, Wang, Hanying, Shen, Qi, Feng, Lifeng, Jin, Hongchuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2017; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/337/384/2568; 631/80/82/39; 631/80/86; 692/53; Antibodies; Autophagy; Autophagy - genetics; Biochemistry; Cancer; Cardiovascular Diseases - genetics; Cardiovascular Diseases - pathology; Cell Biology; Cell Culture; Diabetes mellitus; Diabetes Mellitus - genetics; Diabetes Mellitus - pathology; Gene Expression Regulation; Gene regulation; Homeostasis; Humans; Immunology; Ischemia; Life Sciences; Neoplasms - genetics; Neoplasms - pathology; Organelles; Phagocytosis; Review; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; Signal transduction; Stroke - genetics
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/cddis.2017.464

Autophagy degrades non-functioning or damaged proteins and organelles to maintain cellular homeostasis in a physiological or pathological context. Autophagy can be protective or detrimental, depending on its activation status and other conditions. Therefore, autophagy has a crucial role in a myriad of pathophysiological processes. From the perspective of autophagy-related ( ATG ) genes, the molecular dissection of autophagy process and the regulation of its level have been largely unraveled. However, the discovery of long non-coding RNAs (lncRNAs) provides a new paradigm of gene regulation in almost all important biological processes, including autophagy. In this review, we highlight recent advances in autophagy-associated lncRNAs and their specific autophagic targets, as well as their relevance to human diseases such as cancer, cardiovascular disease, diabetes and cerebral ischemic stroke.