Delayed Results of Transplantation of Fetal Neurogenic Tissue in Patients with Consequences of Spinal Cord Trauma

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 4; pp. 530 - 533
• Main Authors: Seledtsova, G. V, Rabinovich, S. S, Belogorodtsev, S. N, Parlyuk, O. V, Seledtsov, V. I, Kozlov, V. A
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.10.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell Biology; Cell Transplantation; Cysts - therapy; Female; fetal neurogenic cells; Fetal Research; functional deficit; Humans; Internal Medicine; Laboratory Medicine; Liver - embryology; Liver Transplantation; Male; Middle Aged; Nerve Tissue - transplantation; Pathology; Recovery of Function - physiology; Spinal cord injuries; Spinal Cord Injuries - pathology; Spinal Cord Injuries - therapy; spinal cord injury; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); transplantation; spinal cord injury; fetal neurogenic cells; transplantation; functional deficit
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-0985-1

We analyzed delayed effects of transplantation of nervous and hemopoietic fetal cells to patients with consequences of spinal trauma. A decrease in neurological deficit associated with pronounced improvement of functional independence was observed in 48.9% cases. The best results were observed in patients receiving cell transplantation within the first 2 years after trauma and in younger individuals. The pattern of morphological changes in the spinal cord at site of injury, severity of damage, and the method of transplantation had no appreciable effects on its delayed results.