Bronchial blood supply after lung transplantation without bronchial artery revascularization

This review discusses how the bronchial artery circulation is interrupted following lung transplantation and what may be the long-term complications of compromising systemic blood flow to allograft airways. Preclinical and clinical studies have shown that the loss of airway microcirculations is high...

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Bibliographic Details
Published inCurrent opinion in organ transplantation Vol. 15; no. 5; p. 563
Main Authors Nicolls, Mark R, Zamora, Martin R
Format Journal Article
LanguageEnglish
Published United States 01.10.2010
Subjects
Anastomosis, Surgical
Animals
Bronchial Arteries - physiopathology
Bronchial Arteries - surgery
Bronchiolitis Obliterans - etiology
Bronchiolitis Obliterans - physiopathology
Graft Rejection - etiology
Graft Rejection - physiopathology
Graft Survival
Humans
Lung - blood supply
Lung - surgery
Lung Transplantation - adverse effects
Pulmonary Circulation
Regional Blood Flow
Reperfusion Injury - etiology
Reperfusion Injury - physiopathology
Transplantation, Homologous
Treatment Outcome
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Summary:This review discusses how the bronchial artery circulation is interrupted following lung transplantation and what may be the long-term complications of compromising systemic blood flow to allograft airways. Preclinical and clinical studies have shown that the loss of airway microcirculations is highly associated with the development of airway hypoxia and an increased susceptibility to chronic rejection. The bronchial artery circulation has been highly conserved through evolution. Current evidence suggests that the failure to routinely perform bronchial artery revascularization at the time of lung transplantation may predispose patients to develop the bronchiolitis obliterans syndrome.
ISSN:1531-7013
DOI:10.1097/mot.0b013e32833deca9