Disease recurrence in a transplant kidney in a patient with extramedullary plasmacytoma

• Published in: Indian journal of medical and paediatric oncology Vol. 31; no. 3; pp. 91 - 93
• Main Authors: Binnani, Pooja, Bahadur, M M, Kedia, Nikhil, Sharbidre, Prakash
• Format: Journal Article
• Language: English
• Published: A-12, 2nd Floor, Sector 2, Noida-201301 UP, India Thieme Medical and Scientific Publishers Pvt. Ltd 01.07.2010; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications
• Subjects: Care and treatment; CASE REPORT; Case studies; Chemotherapy; Diagnosis; Disease; Diseases; Health aspects; Infections; Kidneys; Light; Medical treatment; Organ transplant recipients; Plasma; Plasmacytoma; Relapse; Risk factors; Transplantation; Transplants & implants; India; Cast nephropathy; disease recurrence; plasmacytoma
• ISSN: 0971-5851; 0975-2129
• DOI: 10.4103/0971-5851.73600

Abstract Renal transplantation in patients with malignancy is controversial. Renal transplantation is generally not considered for patients with multiple myeloma (MM) because of their extremely poor prognosis. There are few reports of MM recurrence among kidney transplant recipients. We present a case of disease relapse of plasmacytoma in a transplanted kidney. We present a patient with extramedullary plasmacytoma, who responded well to chemotherapy and underwent allogenic renal transplantation. He relapsed after 4 years with progression to extramedullary plasmacytoma. Despite minimal clinical symptoms, the patient had developed myeloma cast nephropathy and acute renal failure. His renal failure settled after excision of tumor. Extramedullary plasmacytoma as a mode of relapse is highly unusual. Experience of renal transplantation in MM is limited. In the literature, the recurrence of MM is mentioned as a severe complication with a poor graft prognosis. Extramedullary plasmacytoma as a mode of relapse is highly unusual. It should not be considered as a contraindication for transplantation. Renal transplantation for patients with end stage renal disease (ESRD) due to MM is possible. But large prospective studies are needed to develop a strategy for preventing multiple myeloma recurrence.