From polyploidy to aneuploidy, genome instability and cancer
Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well understood. During evolution, polyploidy is thought to be an important mechanism that contributes to speciation. Polyploid, usually non-dividing, cells are formed during develop...
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Published in | Nature reviews. Molecular cell biology Vol. 5; no. 1; pp. 45 - 54 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.01.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well understood. During evolution, polyploidy is thought to be an important mechanism that contributes to speciation. Polyploid, usually non-dividing, cells are formed during development in otherwise diploid organisms. A growing amount of evidence indicates that polyploid cells also arise during a variety of pathological conditions. Genetic instability in these cells might provide a route to aneuploidy and thereby contribute to the development of cancer. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 1471-0072 1471-0080 |
DOI: | 10.1038/nrm1276 |