From polyploidy to aneuploidy, genome instability and cancer

Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well understood. During evolution, polyploidy is thought to be an important mechanism that contributes to speciation. Polyploid, usually non-dividing, cells are formed during develop...

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Bibliographic Details
Published inNature reviews. Molecular cell biology Vol. 5; no. 1; pp. 45 - 54
Main Authors Pellman, David, Storchova, Zuzana
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.01.2004
Subjects
Aneuploidy
Animals
Biological Evolution
Cancer
Cell cycle
Cell division
Chromosomes
Evolution
Genomes
Genomic Instability - genetics
Humans
Insects
Models, Genetic
Neoplasms - genetics
Oncology
Organisms
Pediatrics
Polyploidy
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Summary:Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well understood. During evolution, polyploidy is thought to be an important mechanism that contributes to speciation. Polyploid, usually non-dividing, cells are formed during development in otherwise diploid organisms. A growing amount of evidence indicates that polyploid cells also arise during a variety of pathological conditions. Genetic instability in these cells might provide a route to aneuploidy and thereby contribute to the development of cancer.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm1276