Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer

Recent studies have indicated that long noncoding RNAs (lncRNAs) play a pivotal role in almost all physiological cellular processes, including every stage of cancer development. Given that hypoxia in the tumor microenvironment is involved in the malignant behavior of tumors, such as invasion and met...

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Published inInternational journal of oncology Vol. 52; no. 2; pp. 453 - 460
Main Authors Nishizawa, Yujiro, Konno, Masamitsu, Asai, Ayumu, Koseki, Jun, Kawamoto, Koichi, Miyoshi, Norikatsu, Takahashi, Hidekazu, Nishida, Naohiro, Haraguchi, Naotsugu, Sakai, Daisuke, Kudo, Toshihiro, Hata, Taishi, Matsuda, Chu, Mizushima, Tsunekazu, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.02.2018
Spandidos Publications UK Ltd
Subjects
Anoxia
Apoptosis
Care and treatment
Cell growth
Chromosomes
Colorectal cancer
Cytoplasm
Development and progression
Epigenetics
Gene expression
Genetic aspects
Genotypes
Health aspects
Hypoxia
Localization
Medical prognosis
Metabolism
Metastasis
MicroRNAs
Mutation
Proteins
Studies
Tumors
United States > US
Japan
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Summary:Recent studies have indicated that long noncoding RNAs (lncRNAs) play a pivotal role in almost all physiological cellular processes, including every stage of cancer development. Given that hypoxia in the tumor microenvironment is involved in the malignant behavior of tumors, such as invasion and metastasis, we investigated the cytoplasmic and nuclear localization of lncRNAs in colorectal cancer cells. A cell culture under hypoxic conditions revealed several lncRNAs, such as LINC00152, whose levels were increased in the cytoplasm of colorectal cancer cells. A database study indicated that LINC00152 shares microRNA-binding sites, such as miR-138 and miR-193, with the hypoxia-inducible factor 1 (HIF1), thus suggesting that LINC00152 could possibly function as a competing endogenous RNA that can augment Hif1 translation in the cytoplasm of hypoxic colorectal cancer cells. Moreover, the data presented in the studies of surgically resected samples showed that patients with colorectal cancer exhibiting high LINC00152 expression were associated with a worsened survival rate; this supports the suggested oncogenic function of LINC00152 in the cytoplasm under hypoxic conditions. The present study demonstrated that lncRNA networks could provide diagnostic tools and novel therapeutic targets against colorectal cancer cells.
ISSN:1019-6439
1791-2423
DOI:10.3892/ijo.2017.4218