New algorithm for valganciclovir dosing in pediatric solid organ transplant recipients

• Published in: Pediatric transplantation Vol. 18; no. 1; pp. 103 - 111
• Main Authors: Åsberg, A., Bjerre, A., Neely, M.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.02.2014
• Subjects: Adolescent; Algorithms; Antiviral Agents - administration & dosage; Area Under Curve; Child; Child, Preschool; Computer Simulation; cytomegalovirus; Cytomegalovirus Infections - drug therapy; Drug Monitoring - methods; Female; Ganciclovir - administration & dosage; Ganciclovir - analogs & derivatives; Glomerular Filtration Rate; Humans; Infant; Male; Models, Theoretical; Monte Carlo Method; Organ Transplantation - methods; Original; pediatric transplantation; population model; Probability; solid organ transplantation; therapeutic drug monitoring; valganciclovir; valganciclovir; population model; solid organ transplantation; pediatric transplantation; cytomegalovirus; therapeutic drug monitoring

CMV infections are common after SOT. v‐GCV is increasingly used in children. The aim of this study was to evaluate presently used dosing algorithms. Data from 104 pediatric SOT recipients (kidney, liver, and heart) aged 0.3–16.9 yr and receiving v‐GCV once a day were used for model development and v...