Insulin-like growth factor II mRNA-binding protein 3: A novel prognostic biomarker for oral squamous cell carcinoma

• Published in: Head & neck Vol. 33; no. 3; pp. 368 - 374
• Main Authors: Li, Shengjin, Cha, JeongDan, Kim, Jin, Kim, Ki-Yeol, Kim, Hyung-Jun, Nam, Woong, Cha, In-Ho
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2011; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Biological and medical sciences; biomarkers; Biomarkers, Tumor - blood; Biopsy, Needle; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - mortality; Chi-Square Distribution; clinicopathologic factors; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Head; Humans; Immunohistochemistry; IMP3; Insulin-Like Growth Factor Binding Protein 3 - blood; Insulin-like growth factor II; Insulin-Like Growth Factor II - metabolism; Kaplan-Meier Estimate; Lymph nodes; Male; Medical sciences; Metastases; Middle Aged; Mouth Neoplasms - blood; Mouth Neoplasms - genetics; Mouth Neoplasms - mortality; Multivariate Analysis; Neck; Neoplasm Staging; oral squamous cell carcinoma; Otorhinolaryngology. Stomatology; Predictive Value of Tests; Prognosis; prognostic factor; Retrospective Studies; RNA, Messenger - analysis; Sensitivity and Specificity; Statistics, Nonparametric; survival; Survival Rate; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Western blotting; Prognosis; prognostic factor; Stomatology; IMP3; Biological marker; ENT; Malignant tumor; Oral squamous cell carcinoma; Insulin; Survival; Binding protein; Messenger RNA; Oral cavity disease; clinicopathologic factors; Cancer; Growth factor
• ISSN: 1043-3074; 1097-0347; 1097-0347
• DOI: 10.1002/hed.21457

Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin‐like growth factor II mRNA‐binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3 can be used as a prognostic biomarker for OSCC. Methods. We performed immunohistochemistry and Western blotting to examine IMP3 expression in human tissues. We also investigated correlations among IMP3 expression, clinicopathologic factors, and overall survival. Results. IMP3 was overexpressed in OSCC cells. The expression was correlated with high histologic grade, lymph node metastasis, and advanced tumor and clinical stages. Univariate analysis indicated that advanced clinical stages, lymph node metastases, and IMP3 expression were predictive factors for OSCC. Multivariate analysis showed that IMP3 expression was an independent prognostic indicator for OSCC. Conclusions. IMP3 expression was related to various clinicopathologic factors. IMP3 expression was an independent prognostic factor in patients with OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010