Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism

Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty‐three subjects with hypoparathyroidism and 33 age‐ and sex‐matched control subjects with no known...

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Published inJournal of bone and mineral research Vol. 23; no. 12; pp. 2018 - 2024
Main Authors Rubin, Mishaela R, Dempster, David W, Zhou, Hua, Shane, Elizabeth, Nickolas, Thomas, Sliney, James, Silverberg, Shonni J, Bilezikian, John P
Format Journal Article
LanguageEnglish
Published Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.12.2008
Amer Soc Bone & Mineral Res
Subjects
Adult
Animals
Biopsy
Bone and Bones - metabolism
Bone and Bones - pathology
bone densitometry
Bone Density
bone histomorphometry
Case-Control Studies
Cohort Studies
Densitometry - methods
Female
Humans
hypoparathyroidism
Hypoparathyroidism - pathology
Male
Middle Aged
Original
parathyroid
Postmenopause
Premenopause
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Abstract Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty‐three subjects with hypoparathyroidism and 33 age‐ and sex‐matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double‐labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean ± SD; BV/TV: 23.5 ± 8 versus 19.7 ± 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 ± 37 versus 119.3 ± 21 μm, p = 0.03), and cortical width (Ct.Wi: 923.4 ± 420 versus 753.5 ± 246 μm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 ± 1.58 versus 4.27 ± 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 ± 0.014 versus 0.032 ± 0.028 μm3/μm2/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
AbstractList Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean ± SD; BV/TV: 23.5 ± 8 versus 19.7 ± 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 ± 37 versus 119.3 ± 21 μm, p = 0.03), and cortical width (Ct.Wi: 923.4 ± 420 versus 753.5 ± 246 μm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 ± 1.58 versus 4.27 ± 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 ± 0.014 versus 0.032 ± 0.028 μm3/μm2/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean ± SD; BV/TV: 23.5 ± 8 versus 19.7 ± 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 ± 37 versus 119.3 ± 21 μm, p = 0.03), and cortical width (Ct.Wi: 923.4 ± 420 versus 753.5 ± 246 μm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 ± 1.58 versus 4.27 ± 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 ± 0.014 versus 0.032 ± 0.028 μm 3 /μm 2 /d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean plus or minus SD; BV/TV: 23.5 plus or minus 8 versus 19.7 plus or minus 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 plus or minus 37 versus 119.3 plus or minus 21 mu m, p = 0.03), and cortical width (Ct.Wi: 923.4 plus or minus 420 versus 753.5 plus or minus 246 mu m, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 plus or minus 1.58 versus 4.27 plus or minus 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 plus or minus 0.014 versus 0.032 plus or minus 0.028 mu m super(3)/ mu m super(2)/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean +/- SD; BV/TV: 23.5 +/- 8 versus 19.7 +/- 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 +/- 37 versus 119.3 +/- 21 microm, p = 0.03), and cortical width (Ct.Wi: 923.4 +/- 420 versus 753.5 +/- 246 microm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 +/- 1.58 versus 4.27 +/- 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 +/- 0.014 versus 0.032 +/- 0.028 microm(3)/microm(2)/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean +/- SD; BV/TV: 23.5 +/- 8 versus 19.7 +/- 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 +/- 37 versus 119.3 +/- 21 microm, p = 0.03), and cortical width (Ct.Wi: 923.4 +/- 420 versus 753.5 +/- 246 microm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 +/- 1.58 versus 4.27 +/- 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 +/- 0.014 versus 0.032 +/- 0.028 microm(3)/microm(2)/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean +/- SD; BV/TV: 23.5 +/- 8 versus 19.7 +/- 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 +/- 37 versus 119.3 +/- 21 microm, p = 0.03), and cortical width (Ct.Wi: 923.4 +/- 420 versus 753.5 +/- 246 microm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 +/- 1.58 versus 4.27 +/- 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 +/- 0.014 versus 0.032 +/- 0.028 microm(3)/microm(2)/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Author Rubin, Mishaela R
Zhou, Hua
Shane, Elizabeth
Bilezikian, John P
Dempster, David W
Nickolas, Thomas
Sliney, James
Silverberg, Shonni J
AuthorAffiliation College of Physicians and Surgeons, Columbia University, New York, New York, USA
AuthorAffiliation_xml – name: College of Physicians and Surgeons, Columbia University, New York, New York, USA
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  givenname: David W
  surname: Dempster
  fullname: Dempster, David W
– sequence: 3
  givenname: Hua
  surname: Zhou
  fullname: Zhou, Hua
– sequence: 4
  givenname: Elizabeth
  surname: Shane
  fullname: Shane, Elizabeth
– sequence: 5
  givenname: Thomas
  surname: Nickolas
  fullname: Nickolas, Thomas
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  givenname: James
  surname: Sliney
  fullname: Sliney, James
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  surname: Silverberg
  fullname: Silverberg, Shonni J
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  givenname: John P
  surname: Bilezikian
  fullname: Bilezikian, John P
BackLink https://www.ncbi.nlm.nih.gov/pubmed/18684087$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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Copyright © 2008 by the American Society for Bone and Mineral Research 2008
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Snippet Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of...
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wiley
SourceType Open Access Repository
Aggregation Database
Index Database
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StartPage 2018
SubjectTerms Adult
Animals
Biopsy
Bone and Bones - metabolism
Bone and Bones - pathology
bone densitometry
Bone Density
bone histomorphometry
Case-Control Studies
Cohort Studies
Densitometry - methods
Female
Humans
hypoparathyroidism
Hypoparathyroidism - pathology
Male
Middle Aged
Original
parathyroid
Postmenopause
Premenopause
Title Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism
URI https://onlinelibrary.wiley.com/doi/abs/10.1359%2Fjbmr.080803
https://www.ncbi.nlm.nih.gov/pubmed/18684087
https://www.proquest.com/docview/19663433
https://www.proquest.com/docview/69826247
https://pubmed.ncbi.nlm.nih.gov/PMC2686925
Volume 23
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