Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism

Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty‐three subjects with hypoparathyroidism and 33 age‐ and sex‐matched control subjects with no known...

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Published inJournal of bone and mineral research Vol. 23; no. 12; pp. 2018 - 2024
Main Authors Rubin, Mishaela R, Dempster, David W, Zhou, Hua, Shane, Elizabeth, Nickolas, Thomas, Sliney, James, Silverberg, Shonni J, Bilezikian, John P
Format Journal Article
LanguageEnglish
Published Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.12.2008
Amer Soc Bone & Mineral Res
Subjects
Adult
Animals
Biopsy
Bone and Bones - metabolism
Bone and Bones - pathology
bone densitometry
Bone Density
bone histomorphometry
Case-Control Studies
Cohort Studies
Densitometry - methods
Female
Humans
hypoparathyroidism
Hypoparathyroidism - pathology
Male
Middle Aged
Original
parathyroid
Postmenopause
Premenopause
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Summary:Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty‐three subjects with hypoparathyroidism and 33 age‐ and sex‐matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double‐labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean ± SD; BV/TV: 23.5 ± 8 versus 19.7 ± 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 ± 37 versus 119.3 ± 21 μm, p = 0.03), and cortical width (Ct.Wi: 923.4 ± 420 versus 753.5 ± 246 μm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 ± 1.58 versus 4.27 ± 3.32%, p < 0.0001) and bone formation rate (BFR/BS: 0.006 ± 0.014 versus 0.032 ± 0.028 μm3/μm2/d, p < 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.
Bibliography:Dr Bilezikian states financial conflicts with Mercy & Co., Eli Lilly & Co., and Novartis Pharmaceuticals. All other authors state that they have no conflicts of interest.
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ISSN:0884-0431
1523-4681
1523-4681
DOI:10.1359/jbmr.080803