Performance of the [13C]-acetate gastric emptying breath test during physical exercise
Background The gastric emptying rate of liquids can be determined non‐invasively using the [13C]‐acetate breath test at rest. The aims of our study were to validate this test during physical exercise against the double‐sampling method and to evaluate the time needed for intestinal absorption and the...
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Published in | European journal of clinical investigation Vol. 29; no. 11; pp. 922 - 928 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford BSL
Blackwell Science Ltd
01.11.1999
Blackwell Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Background
The gastric emptying rate of liquids can be determined non‐invasively using the [13C]‐acetate breath test at rest. The aims of our study were to validate this test during physical exercise against the double‐sampling method and to evaluate the time needed for intestinal absorption and the delay between absorption and appearance of 13CO2 in breath, both at rest and during exercise.
Design
Fifteen well‐trained male subjects were investigated. Gastric emptying was determined simultaneously measuring the 13CO2 breath enrichment after intragastric administration of 0.5 L of carbohydrate solution with 150 mg of [13C]‐acetate added and by the double‐sampling technique (n = 9). In separate tests, 150 mg of [13C]‐acetate was also applied intraduodenally and intravenously (n = 6), both at rest and during exercise. Time‐to‐peak (TTP) 13CO2 enrichment was determined using a curve fit and was considered as the parameter for gastric emptying.
Results
TTP enrichment derived from the breath test significantly correlated with the gastric emptying half‐time obtained from the gastric aspirates. During exercise, median TTP enrichment values after intragastric, intraduodenal (i.d.) and intravenous (i.v.) administration of [13C]‐acetate were 22.3, 10.3 and 5.4 min respectively. During exercise, i.d. and i.v. values were reached significantly earlier than at rest.
Conclusion
The [13C]‐acetate breath test can be used as a non‐invasive method to determine relative gastric emptying rates of liquids during exercise, but the results are influenced by the rate of absorption and the time needed for subsequent oxidation of [13C]‐acetate and exhalation of 13CO2. |
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Bibliography: | istex:69D989D741551A6B3DA80CA9BF017FCDCF2DDDB2 ark:/67375/WNG-F85RMH49-5 ArticleID:ECI546 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0014-2972 1365-2362 |
DOI: | 10.1046/j.1365-2362.1999.00546.x |