Studies on Aldose Reductase Inhibitors from Natural Products. IV. Constituents and Aldose Reductase Inhibitory Effect of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas

The hot water extracts of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas, were found to have potent inhibitory activity towards lens aldose reductase (AR). Ellagic acid (4) was isolated from C. morifolium and I. batatas, isoscutellarein (7) from B. orellana and 3, 5-dicaffeoylquinic aci...

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Published inChem. Pharm. Bull Vol. 39; no. 12; pp. 3346 - 3347
Main Authors SHIMIZU, Mineo, TERASHIMA, Satoshi, HORIE, Syunji, MORITA, Naokata
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1991
公益社団法人日本薬学会
Maruzen
Subjects
3, 5-dicaffeoylquinic acid
Aldehyde Reductase - antagonists & inhibitors
aldose reductase inhibitor
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Bixa orellana
Chrysanthemum morifolium
Drugs, Chinese Herbal - pharmacology
ellagic acid
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Ipomoea batatas
isoscutellarein
Oxidoreductases
Rats
Aldose reductase
Enzyme inhibitor
Enzyme
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.39.3346

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Summary:The hot water extracts of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas, were found to have potent inhibitory activity towards lens aldose reductase (AR). Ellagic acid (4) was isolated from C. morifolium and I. batatas, isoscutellarein (7) from B. orellana and 3, 5-dicaffeoylquinic acid (10) from I. batatas, respectively, as potent inhibitors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.3346