High-intensity Nd:YAG laser accelerates bone regeneration in calvarial defect models
High‐power pulsed lasers have been recently regarded to be anabolic to bone, but in vivo evidence is still lacking. This study aimed to investigate the capacity of bone repair using a high‐power, Q‐switched, pulsed, neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser, using bilateral calvarial d...
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Published in | Journal of tissue engineering and regenerative medicine Vol. 9; no. 8; pp. 943 - 951 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.08.2015
Hindawi Limited |
Subjects | |
Online Access | Get full text |
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Summary: | High‐power pulsed lasers have been recently regarded to be anabolic to bone, but in vivo evidence is still lacking. This study aimed to investigate the capacity of bone repair using a high‐power, Q‐switched, pulsed, neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser, using bilateral calvarial defect models having non‐critical sized, 5 mm (rat) or 8 mm (rabbit) diameter. One of the bilateral defects, which were all filled with collagen sponge or left empty, was irradiated with a Nd:YAG laser once every 2 days for 2 weeks at a constant total fluence rate (344 J/cm2), output power (0.75 W), pulse repetition rate (15 pps) and wavelength (1064 nm) and examined for the laser effect. The same experimental scheme was designed using a rabbit calvarial defect model implanted with sponge, which was explored for the dose effect of output power at 0.75 and 3 W with the same quantities of the other parameters. New bone formation was evaluated by micro‐computed tomography‐based analysis and histological observation at 4 weeks after surgery. Laser irradiation significantly increased new bone formation by approximately 45%, not only in the sponge‐filled defects of rats but also when the defects were left empty, compared to the non‐irradiated group. Consistently, both doses of output power (0.75 and 3 W) enhanced new bone formation, but there was no significant difference between the two doses. This study is one of the first to demonstrate the beneficial effect of Nd:YAG lasers on the regeneration of bone defects which were left empty or filled with collagen sponge, suggesting its great potential in postoperative treatment targeting local bone healing. Copyright © 2013 John Wiley & Sons, Ltd. |
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Bibliography: | istex:DAB38C69247B2E6C2DDD709E8DB3A89B6DD31FC0 ArticleID:TERM1845 Ministry of Health & Welfare, Republic of Korea - No. A084359 ark:/67375/WNG-Q96CTGLF-1 These authors contributed equally as first author. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1932-6254 1932-7005 |
DOI: | 10.1002/term.1845 |