Basophils exhibit antibacterial activity through extracellular trap formation

Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report...

Full description

Saved in:
Bibliographic Details
Published inAllergy (Copenhagen) Vol. 70; no. 9; pp. 1184 - 1188
Main Authors Yousefi, S., Morshed, M., Amini, P., Stojkov, D., Simon, D., Gunten, S., Kaufmann, T., Simon, H.‐U.
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.09.2015
Subjects
Allergies
Animals
Bacteria
Bacteria - immunology
basophil extracellular trap
basophils
Basophils - immunology
Basophils - metabolism
Basophils - microbiology
extracellular bacterial killing
Extracellular Traps - immunology
Extracellular Traps - microbiology
Humans
Hypersensitivity - immunology
Hypersensitivity - microbiology
Immunomodulation
innate immunity
Mice
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - microbiology
phagocytosis
Phagocytosis - immunology
phagocytosis
basophils
extracellular bacterial killing
basophil extracellular trap
innate immunity
Online AccessGet full text

Cover

More Information
Summary:Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0105-4538
1398-9995
DOI:10.1111/all.12662