Constipation Is a Frequent Problem Associated with Vascular Complications in Patients with Type 2 Diabetes: A Cross-sectional Study

• Published in: Internal Medicine Vol. 61; no. 9; pp. 1309 - 1317
• Main Authors: Ito, Hiroyuki, Ito, Kiyoko, Tanaka, Mahika, Hokamura, Mayumi, Tanaka, Mari, Kusano, Eiji, Kondo, Jiro, Izutsu, Takuma, Matsumoto, Suzuko, Inoue, Hideyuki, Antoku, Shinichi, Yamasaki, Tomoko, Mori, Toshiko, Togane, Michiko
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.05.2022; Japan Science and Technology Agency
• Subjects: Body mass index; Cardiovascular disease; Constipation; Constipation - epidemiology; Constipation - etiology; Coronary artery disease; coronary heart disease; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - epidemiology; Diabetic Neuropathies - drug therapy; Diabetic neuropathy; Diagnosis; Heart diseases; Humans; Insulin; Internal medicine; laxative; Laxatives; Laxatives - therapeutic use; Original; Patients; type 2 diabetes; constipation; coronary heart disease; type 2 diabetes; laxative; diabetic neuropathy
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.7676-21

Objective Diabetes is recognized as an underlying disease of constipation. However, the prevalence of constipation varies according to the diagnostic criteria applied. We investigated the prevalence of constipation based on the new guideline for constipation in Japanese patients with type 2 diabetes and examined the relationship with the clinical background, including diabetic vascular complications. Methods Questionnaire surveys including items concerning the diagnosis and treatment status of constipation were administered to 410 patients with type 2 diabetes. Results Although 29% of the patients considered that they had experienced constipation (self-judged), only 14% had consulted a physician about constipation. The prevalence of chronic constipation based on the guideline was 26%. After including laxative users, constipation was finally found in 36%. Despite the use of laxatives (n=81), 51% of the patients were still diagnosed with chronic constipation. Patients with constipation (chronic constipation or laxative use) were significantly older and had a longer duration of diabetes than those without constipation. The body mass index (BMI) of patients with constipation (24.9±3.8 kg/m2) was significantly lower than that of those without constipation (26.3±4.6 kg/m2). Diabetic neuropathy (49% vs. 32%) and coronary heart disease (CHD) (27% vs. 13%) were significantly more frequent in the patients with constipation than in those without constipation. A multivariate logistic regression analysis revealed that gender, BMI, diabetic neuropathy, insulin use, and CHD were significantly associated with constipation. Conclusion An accurate diagnosis of constipation is desirable in patients with type 2 diabetes because constipation is independently associated with CHD.