Football training in men with prostate cancer undergoing androgen deprivation therapy: activity profile and short-term skeletal and postural balance adaptations

• Published in: European journal of applied physiology Vol. 116; no. 3; pp. 471 - 480
• Main Authors: Uth, Jacob, Hornstrup, Therese, Christensen, Jesper F., Christensen, Karl B., Jørgensen, Niklas R., Helge, Eva W., Schmidt, Jakob F., Brasso, Klaus, Helge, Jørn W., Jakobsen, Markus D., Andersen, Lars L., Rørth, Mikael, Midtgaard, Julie, Krustrup, Peter
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2016; Springer Nature B.V
• Subjects: Adaptation, Physiological; Aged; Androgen Antagonists - therapeutic use; Androgens; Antineoplastic Agents, Hormonal - therapeutic use; Biomedical and Life Sciences; Biomedicine; Bone Density; Exercise; Exercise Therapy - adverse effects; Exercise Therapy - methods; Football; Global positioning systems; GPS; Human performance; Human Physiology; Humans; Male; Middle Aged; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Occupational Medicine/Industrial Medicine; Original Article; Physical fitness; Postural Balance; Posture; Prostate cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - therapy; Sports Medicine; Denmark; GPS; Bone turnover markers (BTM); Exercise intensity; Association football; Prostate cancer; Bone mineral content (BMC)
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-015-3301-y

Purpose To investigate the activity profile of football training and its short-term effects on bone mass, bone turnover markers (BTMs) and postural balance in men with prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). Methods This was a randomised 12-week study in which men with PCa undergoing ADT were assigned to a football intervention group [FTG, n  = 29, 67 ± 7 (±SD) years] training 2‒3 times per week for 45‒60 min or to a control group ( n  = 28, 66 ± 5 years). The activity profile was measured using a 5-Hz GPS. The outcomes were total body and leg bone mineral content (BMC) and density, BTMs and postural balance. Results In the last part of the 12 weeks, FTG performed 194 ± 41 accelerations and 296 ± 65 decelerations at >0.6 m/s/s and covered a distance of 905 ± 297 m at speeds >6 km/h and 2646 ± 705 m per training session. Analysis of baseline-to-12-week change scores showed between-group differences in favour of FTG in total body BMC [26.4 g, 95 % confidence interval (CI): 5.8–46.9 g, p  = 0.013], leg BMC (13.8 g, 95 % CI: 7.0‒20.5 g, p  < 0.001) and markers of bone formation: P1NP (36.6 µg/L, 95 % CI: 10.4‒62.8 µg/L, p  = 0.008) and osteocalcin (8.6 µg/L, 95 % CI: 3.3‒13.8 µg/L, p  < 0.01). The number of decelerations correlated to the increase in leg BMC ( r  = 0.65, p  = 0.012). No between-group differences were observed for the remaining outcomes. Conclusion Football training involves numerous runs, accelerations and decelerations, which may be linked to marked increases in bone formation markers and preserved bone mass in middle-aged and elderly men with PCa undergoing ADT. Trial registration ClinicalTrials.gov: NCT01711892.