Surgical management and final outcomes of chondrosarcoma of the temporomandibular joint: case series and comprehensive literature review

• Published in: World journal of surgical oncology Vol. 21; no. 1; pp. 1 - 253
• Main Authors: Oh, Hyun Jun, Yoon, Hye-Jung, Huh, Kyung-Hoe, Kim, Bongju, Kwon, Ik-Jae, Kim, Soung Min, Park, Joo Yong, Choi, Sung Weon, Lee, Jong-Ho
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 19.08.2023; BioMed Central; BMC
• Subjects: Biopsy; Bone tumors; Cancer; Care and treatment; Case reports; Chondrosarcoma; Diagnosis; Facial nerve; Facial nerve transection; Literature reviews; Magnetic resonance imaging; Metastasis; Nerve graft; Nerves; Oncology, Experimental; Patients; Prostheses; Radiation therapy; Reconstructive surgery; Surgery; Temporomandibular joint; Temporomandibular joint disorders; TMJ reconstruction; Tomography; Tumors; South Korea; United States > US
• ISSN: 1477-7819; 1477-7819
• DOI: 10.1186/s12957-023-03143-1

Background Surgical management for chondrosarcoma of the temporomandibular joint (TMJ) is challenging due to the anatomical location involving the facial nerve and the functional joint. The purpose of this case series was to analyze the largest number of TMJ chondrosarcoma cases reported from a single institution and to review the literature about chondrosarcoma involving the TMJ. Methods Ten TMJ chondrosarcoma patients at Seoul National University Dental Hospital were included in this study. Radiographic features, surgical approaches, histopathologic subtypes, and treatment modalities were evaluated. All case reports of TMJ chondrosarcoma published in English from 1954 to 2021 were collected under PRISMA guidelines and comprehensively reviewed. Results The lesions were surgically resected in all 10 patients with efforts to preserve facial nerve function. Wide excision including margins of normal tissue was performed to ensure adequate resection margins. All TMJs were reconstructed with a metal condyle except one, which was reconstructed with vascularized costal bone. At last follow-up, all patients were still alive, and there had been no recurrence. Among 47 cases (patients from the literature and our cases), recurrence was specified in 43 and occurred in four (9.5%). Conclusions For surgical management of TMJ chondrosarcoma, wide excision must consider preservation of the facial nerve. Reconstruction using a metal condyle prosthesis and a vascularized free flap is reliable. A more conservative surgical approach correlates with a favorable prognosis for facial nerve recovery. Nevertheless, wide excision is imperative to prevent tumor recurrence. In cases in which the glenoid fossa is unaffected by the tumor, it is deemed unnecessary to reconstruct the glenoid fossa within an oncological setting. Keywords: Chondrosarcoma, Temporomandibular joint, TMJ reconstruction, Facial nerve transection, Nerve graft