On the road to cancer: aneuploidy and the mitotic checkpoint

Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycl...

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Bibliographic Details
Published inNature reviews. Cancer Vol. 5; no. 10; pp. 773 - 785
Main Authors Kops, Geert J. P. L, Cleveland, Don W, Weaver, Beth A. A
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.10.2005
Subjects
Aneuploidy
Cancer
Chromosomal Instability
Control
Genes, Tumor Suppressor
Genetic aspects
Humans
Mitosis
Mitosis - drug effects
Mutation
Neoplasms - drug therapy
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - pathology
Physiological aspects
Signal Transduction
United States
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Summary:Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
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ISSN:1474-175X
1474-1768
DOI:10.1038/nrc1714