Rodent models of cerebral ischemia

The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury--both the mechanisms governing its occurrence and potential therapeutic strategies. Several laboratory rodent species (notably rats and gerbils), which are readily available at relativel...

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Bibliographic Details
Published inStroke (1970) Vol. 20; no. 12; pp. 1627 - 1642
Main Authors GINSBERG, M. D, BUSTO, R
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 01.12.1989
Subjects
550901 - Pathology- Tracer Techniques
ANIMALS
ANOXIA
Arterial Occlusive Diseases - complications
ARTERIES
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD VESSELS
BODY
BODY FLUIDS
BRAIN
Brain Ischemia - etiology
Brain Ischemia - physiopathology
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
Cerebral Arteries
CEREBROSPINAL FLUID
Cerebrospinal Fluid Pressure
Cerebrovascular Disorders - etiology
Disease Models, Animal
DISEASES
DOCUMENT TYPES
Gerbillinae
Hypoxia, Brain - etiology
Intracranial Embolism and Thrombosis - chemically induced
ISCHEMIA
ISOTOPE APPLICATIONS
Light
MAMMALS
MATERIALS
Medical sciences
NERVOUS SYSTEM
Nervous system involvement in other diseases. Miscellaneous
Neurology
Neurology - methods
ORGANS
PATHOGENESIS
Radiation-Sensitizing Agents
RATS
Rats, Inbred SHR
REVIEWS
RODENTS
THROMBOSIS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
Brain
Animal model
Vertebrata
Nervous system diseases
Mammalia
Ischemia
Animal
Rodentia
Bibliographic survey
Technique
Cerebrovascular disease
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Summary:The use of physiologically regulated, reproducible animal models is crucial to the study of ischemic brain injury--both the mechanisms governing its occurrence and potential therapeutic strategies. Several laboratory rodent species (notably rats and gerbils), which are readily available at relatively low cost, are highly suitable for the investigation of cerebral ischemia and have been widely employed for this purpose. We critically examine and summarize several rodent models of transient global ischemia, resulting in selective neuronal injury within vulnerable brain regions, and focal ischemia, typically giving rise to localized brain infarction. We explore the utility of individual models and emphasize the necessity for meticulous experimental control of those variables that modulate the severity of ischemic brain injury.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.20.12.1627