Modelling the impact of vaccination on tuberculosis in badgers

Tuberculosis (TB) in livestock, caused by Mycobacterium bovis, persists in many countries. In the UK and Ireland, efforts to control TB through culling of badgers (Meles meles), the principal wildlife host, have failed and there is significant interest in vaccination of badgers as an alternative or...

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Bibliographic Details
Published inEpidemiology and infection Vol. 141; no. 7; pp. 1417 - 1427
Main Authors HARDSTAFF, J. L., BULLING, M. T., MARION, G., HUTCHINGS, M. R., WHITE, P. C. L.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.07.2013
Subjects
Animals
Badgers
Biological and medical sciences
Cattle
Computer Simulation
Culling
Disease Eradication - methods
Disease models
Disease Reservoirs - veterinary
Disease transmission
Fundamental and applied biological sciences. Psychology
Group size
Infections
Ireland
Livestock
Microbiology
Models, Biological
Mortality
Mustelidae
Mycobacterium bovis
Mycobacterium tuberculosis
Original Papers
Population Control
Population Density
Simulation
Spatial Analysis
Time Factors
Tuberculosis
Tuberculosis - prevention & control
Tuberculosis - veterinary
Tuberculosis vaccine
Ungulates
United Kingdom
Vaccination
Vaccination - methods
Vaccination - veterinary
Vaccines
United Kingdom > UK
Ireland
Europe
zoonoses
Spatial modelling
tuberculosis (TB)
Mycobacteria
vaccine policy development
Epidemiology
Modeling
Vaccination
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Summary:Tuberculosis (TB) in livestock, caused by Mycobacterium bovis, persists in many countries. In the UK and Ireland, efforts to control TB through culling of badgers (Meles meles), the principal wildlife host, have failed and there is significant interest in vaccination of badgers as an alternative or complementary strategy. Using a simulation model, we show that where TB is self-contained within the badger population and there are no external sources of infection, limited-duration vaccination at a high level of efficacy can reduce or even eradicate TB from the badger population. However, where sources of external infection persist, benefits in TB reduction in badgers can only be achieved by ongoing, annual vaccination. Vaccination is likely to be most effective as part of an integrated disease management strategy incorporating a number of different approaches across the entire host community.
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ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268813000642