Complete Genome Sequence of Methanomassiliicoccus luminyensis, the Largest Genome of a Human-Associated Archaea Species

• Published in: Journal of Bacteriology Vol. 194; no. 17; p. 4745
• Main Authors: Gorlas, Aurore, Robert, Catherine, Gimenez, Gregory, Drancourt, Michel, Raoult, Didier
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.09.2012
• Subjects: Archaea; Bacteria; Bacteriology; Base Sequence; Biological and medical sciences; Chromosome Mapping; ecosystems; Euryarchaeota - classification; Euryarchaeota - genetics; Euryarchaeota - isolation & purification; evolution; Feces; Feces - microbiology; Fundamental and applied biological sciences. Psychology; genome; Genome Announcements; Genome, Archaeal; Genomes; horizontal gene transfer; Humans; methanogens; Microbiology; Miscellaneous; Molecular Sequence Data; nucleotide sequences; Phylogeny; RNA, Ribosomal, 16S - genetics; Sequence Analysis, DNA; Human; Bacteria; Nucleotide sequence; Genome; Archaeobacteria
• ISSN: 0021-9193; 1098-5530; 1067-8832; 1098-5530
• DOI: 10.1128/JB.00956-12

The present study describes the complete and annotated genome sequence of Methanomassiliicoccus luminyensis strain B10 (DSM 24529T, CSUR P135), which was isolated from human feces. The 2.6-Mb genome represents the largest genome of a methanogenic euryarchaeon isolated from humans. The genome data of M. luminyensis reveal unique features and horizontal gene transfer events, which might have occurred during its adaptation and/or evolution in the human ecosystem.