Genetic Fine Structure of a Salmonella enterica Serovar Typhi Strain Associated with the 2005 Outbreak of Typhoid Fever in Kelantan, Malaysia

• Published in: Journal of Bacteriology Vol. 194; no. 13; pp. 3565 - 3566
• Main Authors: Baddam, Ramani, Kumar, Narender, Thong, Kwai-Lin, Ngoi, Soo-Tein, Teh, Cindy Shuan Ju, Yap, Kien-Pong, Chai, Lay-Ching, Avasthi, Tiruvayipati Suma, Ahmed, Niyaz
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2012
• Subjects: Bacteriology; Biological and medical sciences; Disease control; Disease Outbreaks; evolution; Fatalities; Fundamental and applied biological sciences. Psychology; genome; Genome Announcements; Genome, Bacterial; Genomics; indigenous species; Malaysia - epidemiology; Microbiology; Miscellaneous; Molecular Sequence Data; nucleotide sequences; pathogens; Salmonella; Salmonella enterica; Salmonella enterica subsp. enterica serovar Typhi; Salmonella typhi; Salmonella typhi - genetics; Salmonella typhi - pathogenicity; Sequence Analysis, DNA; Typhoid; typhoid fever; Typhoid Fever - epidemiology; Typhoid Fever - microbiology; Virulence; Malaysia; Asia; South east Asia; Kelantan Malaysia; Infection; Tropical zone; Bacteriosis; Salmonella typhi; Bacteria; Digestive diseases; Genetics; Salmonellosis; Typhoid; Enterobacteriaceae; Strain
• ISSN: 0021-9193; 1098-5530; 1067-8832
• DOI: 10.1128/JB.00581-12

Among enteric pathogens, Salmonella enterica serovar Typhi is responsible for the largest number of food-borne outbreaks and fatalities. The ability of the pathogen to cause systemic infection for extended durations leads to a high cost of disease control. Chronic carriers play important roles in the evolution of Salmonella Typhi; therefore, identification and in-depth characterization of isolates from clinical cases and carriers, especially those from zones of endemicity where the pathogen has not been extensively studied, are necessary. Here, we describe the genome sequence of the highly virulent Salmonella Typhi strain BL196/05 isolated during the outbreak of typhoid in Kelantan, Malaysia, in 2005. The whole-genome sequence and comparative genomics of this strain should enable us to understand the virulence mechanisms and evolutionary dynamics of this pathogen in Malaysia and elsewhere.