Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod
Urp1 and Urp2 are two neuropeptides of the urotensin II family identified in teleost fish and mainly expressed in cerebrospinal fluid (CSF)-contacting neurons. It has been recently proposed that Urp1 and Urp2 are required for correct axis formation and maintenance. Their action is thought to be medi...
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Published in | Open biology Vol. 11; no. 8; p. 210065 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society
01.08.2021
The Royal Society |
Subjects | |
Online Access | Get full text |
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Summary: | Urp1 and Urp2 are two neuropeptides of the urotensin II family identified in teleost fish and mainly expressed in cerebrospinal fluid (CSF)-contacting neurons. It has been recently proposed that Urp1 and Urp2 are required for correct axis formation and maintenance. Their action is thought to be mediated by the receptor Uts2r3, which is specifically expressed in dorsal somites. In support of this view, it has been demonstrated that the loss of
results in severe scoliosis in adult zebrafish. In the present study, we report for the first time the occurrence of
but not of
, in two tetrapod species of the
genus. In
, we show that
mRNA-containing cells are CSF-contacting neurons. Furthermore, we identified
the
counterparts of zebrafish
and we demonstrate that, as in zebrafish, it is expressed in the dorsal somatic musculature. Finally, we reveal that, in
the disruption of
results in an abnormal curvature of the antero-posterior axis of the tadpoles. Taken together, our results suggest that the role of the Utr4 signalling pathway in the control of body straightness is an ancestral feature of bony vertebrates and not just a peculiarity of ray-finned fishes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: Institut Mondor de Recherche Biomédicale (IMRB) INSERM U955 Université Paris Est, France. These authors contributed equally. Present address: Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, Paris, France. Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5535147. |
ISSN: | 2046-2441 2046-2441 |
DOI: | 10.1098/rsob.210065 |