Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding

• Published in: Molecular and Cellular Biology Vol. 28; no. 15; pp. 4896 - 4914
• Main Authors: Butler, Georgina S., Dean, Richard A., Tam, Eric M., Overall, Christopher M.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.08.2008; Taylor & Francis; American Society for Microbiology (ASM)
• Subjects: Amino Acid Sequence; Breast Neoplasms - enzymology; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - enzymology; Culture Media, Conditioned; Drug Screening Assays, Antitumor; Galectin 1 - metabolism; HSP90 Heat-Shock Proteins - metabolism; Humans; Hydroxamic Acids - pharmacology; Intercellular Signaling Peptides and Proteins - chemistry; Intercellular Signaling Peptides and Proteins - metabolism; Isotope Labeling; Matrix Metalloproteinase 14 - metabolism; Matrix Metalloproteinase Inhibitors; Models, Biological; Molecular Sequence Data; Oncogene Proteins - metabolism; Organic Chemicals - pharmacology; Protease Inhibitors - pharmacology; Proteomics; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases - metabolism; Reproducibility of Results; Substrate Specificity - drug effects
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.01775-07

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