Prevalence of hypothalamo pituitary dysfunction in patients of traumatic brain injury

Background: Traumatic brain injury (TBI) is common in young soldiers of armed forces leading to significant morbidity and mortality. We studied the prevalence of hypopituitarism following TBI and its association with trauma severity. Materials and Methods: We conducted a 12-month prospective study o...

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Published inIndian journal of endocrinology and metabolism Vol. 20; no. 6; pp. 772 - 778
Main Authors Hari Kumar, K. V. S, Swamy, M, Khan, M
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.11.2016
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Brain injuries
Central hypothyroidism
Conflicts of interest
Head injuries
head injury
hypogonadism
Hypopituitarism
Hypothyroidism
Insulin
Intensive care
Mortality
Original
Prevalence studies (Epidemiology)
Risk factors
Testosterone
Thyroid gland
Traumatic brain injury
India
traumatic brain injury
hypopituitarism
hypogonadism
Central hypothyroidism
head injury
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Summary:Background: Traumatic brain injury (TBI) is common in young soldiers of armed forces leading to significant morbidity and mortality. We studied the prevalence of hypopituitarism following TBI and its association with trauma severity. Materials and Methods: We conducted a 12-month prospective study of 56 TBI patients for the presence of hormonal dysfunction. Hormonal parameters were estimated during the early phase (0-10 days posttraumatically) and after 6 and 12 months. Dynamic testing was done when required, and the results were analyzed by appropriate statistical methods. Results: Hormonal dysfunction was seen in 39 of the 56 (70%) patients at initial assessment. Persisting pituitary deficiencies are seen in 7 and 8 patients at the end of 6 months and 12 months, respectively. Hypogonadotropic hypogonadism, hypothyroidism, and growth hormone deficiency are the most common diagnoses. Initial severe TBI and plurihormonal involvement predicted the long-term hypopituitarism. Conclusion: Early hypopituitarism was common in severe TBI, but recovers in majority. Evaluation for the occult pituitary dysfunction is required during the rehabilitation of TBI patients.
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ISSN:2230-8210
2230-9500
DOI:10.4103/2230-8210.192917