Update of Wnt signaling in implantation and decidualization

Embryonic development into an implantation-competent blastocyst, synchronized uterine transformation into a receptive stage, and an intimate cross-talk between the activated blastocyst and the receptive uterus are essential for successful implantation, and therefore for subsequent pregnancy outcome....

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Published inReproductive medicine and biology Vol. 15; no. 2; pp. 95 - 105
Main Authors Zhang, Qian, Yan, Junhao
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.04.2016
John Wiley & Sons, Inc
John Wiley and Sons Inc
Subjects
Decidualization
Embryogenesis
Embryos
Genes
Genomes
Gynecology
Implantation
Insects
Kinases
Ligands
Medicine
Medicine & Public Health
Phosphorylation
Proteins
Reproductive Medicine
Review
Review Article
Signal transduction
Urology
Uterus
Wnt ligands
Wnt protein
Wnt signaling
β‐Catenin
β-Catenin
Implantation
Wnt signaling
Wnt ligands
Decidualization
β‐Catenin
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Summary:Embryonic development into an implantation-competent blastocyst, synchronized uterine transformation into a receptive stage, and an intimate cross-talk between the activated blastocyst and the receptive uterus are essential for successful implantation, and therefore for subsequent pregnancy outcome. Evidence accumulating during recent years has underlined the importance of the Wnt signaling pathway in mammalian implantation and decidualization. Herein, this review focuses on the current state of knowledge regarding Wnt signaling in multiple implantation and decidualization events: pre-implantation embryo development, blastocyst activation for implantation, uterine development, and decidualization.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1445-5781
1447-0578
DOI:10.1007/s12522-015-0226-4