In vitro biocompatibility assessment of sulfonated polyrotaxane-immobilized polyurethane surfaces
Sulfonated polyrotaxanes (PRx‐SO3's), in which sulfonated α‐cyclodextrins (α‐CDs) were threaded onto the poly(ethylene glycol) (PEG) segments in a PEG‐b‐poly(propylene glycol) (PPG)‐b‐PEG triblock copolymer (Pluronic) capped with benzyloxycarbonyl (Z)‐L‐phenylalanine (Z‐L‐Phe), were prepared as...
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Published in | Journal of biomedical materials research. Part A Vol. 66A; no. 3; pp. 596 - 604 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.09.2003
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Subjects | |
Online Access | Get full text |
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Summary: | Sulfonated polyrotaxanes (PRx‐SO3's), in which sulfonated α‐cyclodextrins (α‐CDs) were threaded onto the poly(ethylene glycol) (PEG) segments in a PEG‐b‐poly(propylene glycol) (PPG)‐b‐PEG triblock copolymer (Pluronic) capped with benzyloxycarbonyl (Z)‐L‐phenylalanine (Z‐L‐Phe), were prepared as a novel surface‐modifying biomaterial. Surface modification of the polyurethane (PU) was carried out by blending the PRx‐SO3's with a PU solution, followed by solution casting. The incorporated PRx‐SO3's led to the enhanced hydrophilicity by changing the surface properties of the PU matrix. Modified PUs showed the stable entrapment of the PRx‐SO3's with little extraction into water and enhanced mechanical properties after exposure to water compared to the PU control. The incorporated PRx‐SO3's repelled the proteins and kept them from closely approaching the surface areas, prevented platelet activation by thrombin, and effectively repelled bacteria. These results suggest that both the supramolecular structure of the polyrotaxanes and exposure of the sulfonated groups onto the surfaces contribute to these phenomena. Thus, surface modification with PRx‐SO3's is suggested to be useful for the fabrication of biocompatible medical devices. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A: 596–604, 2003 |
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Bibliography: | istex:F940870A64144114D160D2A6BFD184779F9B388C JAIST International Joint Research Grant and Joint Research Project under the Japan-Korea Basic Scientific Cooperation Program by JSPS and KOSEF ArticleID:JBM10505 ark:/67375/WNG-5LX7XPXW-F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1549-3296 1552-4965 |
DOI: | 10.1002/jbm.a.10505 |