Efficacy of using trimethoprim‐sulfamethoxazole prophylaxis in an adult patient with autoimmune neutropenia

A 63‐year‐old man was admitted for pneumonia with neutropenia. After the pneumonia resolved with administration of antibiotics and granulocyte colony‐stimulating factor, he was diagnosed with autoimmune neutropenia (AIN) on the basis of bone marrow findings and positive antineutrophil antibodies. He...

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Published inJournal of general and family medicine Vol. 20; no. 5; pp. 199 - 202
Main Authors Azuma, Naoto, Sekiguchi, Masahiro, Matsunaga, Hitomi, Sano, Hajime, Matsui, Kiyoshi
Format Journal Article
LanguageEnglish
Published Japan John Wiley & Sons, Inc 01.09.2019
John Wiley and Sons Inc
Wiley
Subjects
adult
Adults
Antibiotics
autoimmune neutropenia
Bacterial infections
Bone marrow
Case Report
Case Reports
Chemotherapy
Diabetes
Drug dosages
Granulocytes
Hepatitis
Immunoglobulins
Infections
Microorganisms
Neutropenia
Neutrophils
Patients
Pharmaceuticals
Pneumonia
prophylaxis
trimethoprim‐sulfamethoxazole
autoimmune neutropenia
trimethoprim‐sulfamethoxazole
adult
prophylaxis
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Summary:A 63‐year‐old man was admitted for pneumonia with neutropenia. After the pneumonia resolved with administration of antibiotics and granulocyte colony‐stimulating factor, he was diagnosed with autoimmune neutropenia (AIN) on the basis of bone marrow findings and positive antineutrophil antibodies. He had recurring high fever once or twice a month with productive cough and an elevated serum C‐reactive protein level. However, after the initiation of treatment with oral trimethoprim‐sulfamethoxazole (TMP/SMX), the respiratory tract infection no longer recurred. The standard management for adults with AIN has not been established. In our case, the recurrent infection was resolved with TMP/SMX prophylaxis. Thus, TMP/SMX prophylaxis may be beneficial for managing adults with AIN.
ISSN:2189-7948
2189-6577
2189-7948
DOI:10.1002/jgf2.254