Recent knowledge: Concepts of dermal absorption in relation to skin decontamination

• Published in: Journal of applied toxicology Vol. 36; no. 1; pp. 5 - 9
• Main Authors: Phuong, Christina, Maibach, Howard I.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2016; Wiley Subscription Services, Inc
• Subjects: Animals; Biocompatibility; Biological; Decontamination; Dermal absorption; detergents; Disinfectants - pharmacology; Epidermis - metabolism; Heterogeneity; Humans; In vitro testing; Membranes; model membrane; Partitioning; percutaneous penetration; Phthalic Acids - pharmacokinetics; Skin; Skin Absorption; skin wipes; stratum corneum (SC); Toxicology; partitioning; percutaneous penetration; stratum corneum (SC); skin wipes; model membrane; detergents
• ISSN: 0260-437X; 1099-1263
• DOI: 10.1002/jat.3222

Skin decontamination is an important step mitigating percutaneous absorption through the stratum corneum (SC), which is also a highly complex process. Thus, understanding diffusion mechanisms and measuring dermal absorption rates are critical to protect humans from toxic exposures. Here, highly varied literature is placed in a biological and clinical perspective in regards to decontamination. Literature from PubMed and Surge Laboratory library files were searched and reviewed for relevance. Recent data have shown multiple layers of SC structural heterogeneity, which results in unique substance partitioning characteristics across the membrane. As such, attempts to model and understand this behavior in alternative in vitro membranes prove difficult. More synthetic and natural membranes are being explored as models for in vivo behavior. In addition, commonly accepted decontamination methods are undergoing risk assessment. These recent and varied literature findings update available knowledge regarding skin decontamination and its challenges, with a focus on dermal absorption. Copyright © 2015 John Wiley & Sons, Ltd. Understanding mechanisms of skin decontamination is critical to protecting humans from percutaneous absorption of toxicants through stratum corneum. Here, highly varied literature is placed in a biological and clinical perspective regarding decontamination, focusing on dermal absorption. Stratum corneum structural heterogeneity results in unique substance partitioning characteristics. As such, attempts to model this behavior in alternative in vitro membranes prove difficult. Further, common decontamination methods are undergoing risk assessment. These recent findings update available knowledge regarding skin decontamination and its challenges.