Antiosteoporotic activity of Dae-Bo-Won-Chun in Ovariectomized rats

• Published in: Phytotherapy research Vol. 15; no. 1; pp. 53 - 57
• Main Authors: Chae, Han-Jung, Kang, Jang-Sook, Kim, Jong-Hwan, Kim, Chul-Won, Yoo, Sim-Keun, Shin, Tae-Yong, Choi, Bom, Kim, Hyung-Min, Kim, Hyung-Ryong
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2001; Wiley
• Subjects: Animals; Biological and medical sciences; bone histomorphometry; DBWC; Disease Models, Animal; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Female; Femur - drug effects; General pharmacology; mechanical strength; Medical sciences; Osteoporosis - prevention & control; Ovariectomy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal; Rats; Rats, Sprague-Dawley; serum biochemistry; Tibia - drug effects; Ovariectomy; Rat; Pharmacognosy; Oriental medicine; Rodentia; Diseases of the osteoarticular system; Bone disease; Medicinal plant; Prevention; Osteoporosis; Vertebrata; Mammalia; Folk medicine; Animal; Plant origin; Female; Phytotherapy
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/1099-1573(200102)15:1<53::AID-PTR732>3.0.CO;2-E

The preventive effect of the herbal formulation, ‘Dae‐Bo‐Won‐Chun’ (DBWC), on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. From light microscope analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in ovariectomized rats, whereas those of the same bone in sham‐operated rats were composed of fine particles. The trabecular bone area and trabecular thickness in ovariectomized rats decreased by 50% from those in sham‐operated rats, these decreases were completely inhibited by administration of DBWC at a concentration of 10 mg/kg per day for 7 weeks. The mechanical strength of the neck of the femur was decreased by ovariectomy, and this was significantly suppressed by the administration of DBWC. Serum phosphorus, alkaline phosphatase and thyroxine levels in ovariectomized rats increased compared with those in sham‐operated rats, and increases were completely inhibited by the administration of DBWC. These results strongly suggest that DBWC is effective in preventing the development of bone loss induced by ovariectomy in rats. Copyright © 2001 John Wiley & Sons, Ltd.