STRUCTURES OF ENZYMATICALLY MODIFIED PRODUCTS OF ARBEKACIN BY METHICILLIN-RESISTANT Staphylococcus aureus

Only a limited number of strains of methicillin-resistant Staphylococcus aureus (MRSA) moderately resistant to arbekacin (ABK) have been isolated clinically. Three inactivated products of ABK have been obtained by reaction with excess amounts of a crude enzyme preparation extracted from an ABK-resis...

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Published inJournal of antibiotics Vol. 46; no. 2; pp. 310 - 315
Main Authors KONDO, SHINICHI, TAMURA, ATSUSHI, GOMI, SHUICHI, IKEDA, YOKO, TAKEUCHI, TOMIO, MITSUHASHI, SUSUMU
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1993
Subjects
Aminoglycosides
Anti-Bacterial Agents
Dibekacin - analogs & derivatives
Dibekacin - chemistry
Dibekacin - metabolism
Dibekacin - pharmacology
Inactivation, Metabolic
Magnetic Resonance Spectroscopy
Methicillin Resistance
Staphylococcus aureus - drug effects
Staphylococcus aureus - metabolism
Staphylococcus aureus
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Summary:Only a limited number of strains of methicillin-resistant Staphylococcus aureus (MRSA) moderately resistant to arbekacin (ABK) have been isolated clinically. Three inactivated products of ABK have been obtained by reaction with excess amounts of a crude enzyme preparation extracted from an ABK-resistant MRSA strain (MIC, 25μg/ml). The 2''-O-phosphate was the major product together with small amounts of the 6'-N-acetate and the double modification product. The structures of these modification products were determined by MS and NMR spectral analyses.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.310