Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus

• Published in: Journal of general and applied microbiology Vol. 67; no. 6; pp. 269 - 272
• Main Authors: Pal, Anirban, Darokar, Mahendra P., Singh, Vigyasa
• Format: Journal Article
• Language: English
• Published: Japan Applied Microbiology, Molecular and Cellular Biosciences Research Foundation 01.01.2021; Japan Science and Technology Agency
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antiinfectives and antibacterials; Cell morphology; Cytology; drug resistance; Flavonoids; glabridin; Isoflavones; Lipids; Macromolecules; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Multidrug resistance; Norfloxacin; Norfloxacin - pharmacology; Oxidative stress; Phenols; Prospective Studies; Reactive Oxygen Species; S. aureus; Staphylococcus aureus; glabridin; S. aureus; drug resistance; norfloxacin; reactive oxygen species
• ISSN: 0022-1260; 1349-8037
• DOI: 10.2323/jgam.2021.06.002

Glabridin (Glb), a polyphenolic flavonoid inhibits the growth of MDRSA (Multidrug resistant S. aureus) 4627 by inducing ROS. Glb in combination with Norfloxacin (Nor) synergistically induced oxidative stress. Increased ROS/RNS levels, in particular, affected macromolecules' (DNA, lipid, protein) integrity and distorted cell morphology. We found correlation between drug-effects and up-/down-regulation of oxidative stress-related as well as MDR genes. These findings could considerably potentiate the dosing routine of Nor in combination with Glb, which holds a promising prospective as a antibacterial agent against S. aureus.