Development of Biodegradable Polymeric Stents for the Treatment of Cardiovascular Diseases

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 9; p. 1245
• Main Authors: Shen, Yihong, Yu, Xiao, Cui, Jie, Yu, Fan, Liu, Mingyue, Chen, Yujie, Wu, Jinglei, Sun, Binbin, Mo, Xiumei
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2022; MDPI
• Subjects: Acids; Angioplasty; Arteries; Biodegradability; biodegradable polymeric stents; Biodegradation; Blood vessels; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Catheters; Coronary vessels; Degradability; functionalization; Hyperplasia; Implants; Inflammation; Injection molding; Lasers; Manufacturing; manufacturing method; Materials; Mechanical properties; Methods; Mortality; Plastics; Polymers; Review; Stent (Surgery); Stents; Thrombosis; China
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom12091245

Cardiovascular disease has become the leading cause of death. A vascular stent is an effective means for the treatment of cardiovascular diseases. In recent years, biodegradable polymeric vascular stents have been widely investigated by researchers because of its degradability and clinical application potential for cardiovascular disease treatment. Compared to non-biodegradable stents, these stents are designed to degrade after vascular healing, leaving regenerated healthy arteries. This article reviews and summarizes the recent advanced methods for fabricating biodegradable polymeric stents, including injection molding, weaving, 3D printing, and laser cutting. Besides, the functional modification of biodegradable polymeric stents is also introduced, including visualization, anti-thrombus, endothelialization, and anti-inflammation. In the end, the challenges and future perspectives of biodegradable polymeric stents were discussed.