Rat Obesity Gene Fatty (fa) Maps to Chromosome 5: Evidence for Homology with the Mouse Gene Diabetes (db)

The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that develop early and ultimately become severe. Although both fa/fa rats and db/db mice have been studied extensively as models of human obesity and diabetes, the molecular bases of these phenotypes remain unknown. We...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 88; no. 17; pp. 7806 - 7809
Main Authors TRUETT, G. E, BAHARY, N, FRIEDMAN, J. M, LEIBEL, R. L
Format Journal Article
LanguageEnglish
Published Washington, DC National Academy of Sciences of the United States of America 01.09.1991
National Acad Sciences
Subjects
Alleles
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Chromosomes
Classical genetics, quantitative genetics, hybrids
Crosses, Genetic
Diabetes
Diabetes Mellitus, Experimental - genetics
Female
Fundamental and applied biological sciences. Psychology
Genes
Genetic Linkage
Genetic loci
Genetic mutation
Genetics of eukaryotes. Biological and molecular evolution
Genomes
Genotype
Male
Mice
Mice, Mutant Strains
Molecular Sequence Data
Obesity
Obesity - genetics
Oligonucleotide Probes
Phenotypes
Rats
Rats, Mutant Strains
Recombination, Genetic
Sequence Homology, Nucleic Acid
Vertebrata
Genetic mapping
Animal model
Obesity
Vertebrata
Mammalia
Rat
Mouse
Linkage group
Rodentia
Homology
Metabolic diseases
Mutation
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Summary:The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that develop early and ultimately become severe. Although both fa/fa rats and db/db mice have been studied extensively as models of human obesity and diabetes, the molecular bases of these phenotypes remain unknown. We have mapped fa in 50 fa/fa (obese) offspring of a (13M x Brown Norway) F1fa/+ intercross relative to two molecular markers, Ifa and Glut-1, which flank db on mouse chromosome 4 and which are located on rat chromosome 5. Ifa and Glut-1 are linked to fa, with a gene order, Ifa-fa-Glut-1, that is identical to that for the region around db in the mouse genome. These results place fa on rat chromosome 5 and suggest that db and fa are mutations in homologous genes.
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ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.88.17.7806