Hydrophobic modification of sodium alginate and its application in drug controlled release

• Published in: Bioprocess and biosystems engineering Vol. 33; no. 4; pp. 457 - 463
• Main Authors: Yao, Bolong, Ni, Caihua, Xiong, Cheng, Zhu, Changping, Huang, Bo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.05.2010; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Alginates - chemistry; Animals; Bioengineering; Biological and medical sciences; Biotechnology; Calcium chloride; Cattle; Chemical engineering; Chemistry; Chemistry and Materials Science; Delayed-Action Preparations; Drug Carriers - chemistry; Environmental Engineering/Biotechnology; Fluorescence; Food Science; Fundamental and applied biological sciences. Psychology; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Industrial and Production Engineering; Industrial Chemistry/Chemical Engineering; Magnetic Resonance Spectroscopy; Microspheres; NMR; Nuclear magnetic resonance; Original Paper; Pharmacology; Polymethacrylic Acids - chemistry; Serum Albumin, Bovine - administration & dosage; Sodium; Spectrometry; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Thermogravimetry; Sodium alginate; Polybutyl methacrylate; Hydrophobic modification; Controlled release; Drug; Sodium; Alginates; Application; Release
• ISSN: 1615-7591; 1615-7605
• DOI: 10.1007/s00449-009-0349-2

Sodium alginate was hydrophobically modified by coupling of polybutyl methacrylate onto the alginate. The polybutyl methacrylate was previously prepared through polymerization of butyl methacrylate in the presence of 2-amino-ethanethiol as a chain transfer agent. The structure of the product was characterized by Fourier-transformed infrared spectrometry, nuclear magnetic resonance (¹HNMR) and thermogravimetry. The result of fluorescence analysis showed that the hydrophobicity of the modified alginate was obviously increased. The modified alginate conjugate was used for immobilization of bovine serum albumin in the presence of calcium chloride. In addition, the release behavior of the drug-loaded alginate in deionized water and Tris-HCl buffer solution (pH 7.2) was investigated. It was found that the modified sodium alginate possessed prolonged release behavior compared to unmodified sodium alginate, and it had potential application in controlled release as a drug carrier.