Biscuit consumption and diabetic retinopathy incidence in adults in the United States

• Published in: Diabetology and metabolic syndrome Vol. 14; no. 1; pp. 1 - 94
• Main Authors: Shi, Ke, Chen, Yuhong, Zhu, Xinyue, Wu, Jiali, Chen, Jieqiong, Hu, Jing, Sun, Xiaodong, Zhang, Jingfa
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 06.07.2022; BioMed Central; BMC
• Subjects: Adults; Alcohol; Analysis; Binary logistic regression model; Biscuit; Blood pressure; Blood sugar; Body mass index; Body weight; Cancer; Diabetes; Diabetes mellitus; Diabetes therapy; Diabetic retinopathy; Diet; Dietary; Ethnicity; Fasting; Food; Glucose; Glycosylated hemoglobin; Hemoglobin; Insulin; Nutrition research; Overweight; Population studies; Regression analysis; Retinopathy; Review boards; Software; Surveys; The National Health and Nutrition Examination Survey; Trends; United States > US
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-022-00860-7

Background Foods have a considerable influence on human health and were directly related to glycemic control for diabetes patients. However, little is known about the effects of biscuits, a traditional food consumed in large amounts in several countries, on diabetic retinopathy. This study aimed to explore the association between biscuit consumption and diabetic retinopathy prevalence in adults of the United States population. Methods A cross-sectional study with 1904 participants from the National Health and Nutrition Examination Survey database were included in this population-based, cross-sectional study. The association between different consumption frequencies of biscuit and diabetic retinopathy prevalence was evaluated using a binary logistic regression model. Trend test, stratified and interaction analyses were also performed. Results After possible confounders including sex, age, ethnicity, education, marital status, family poverty income ratio, smoking and alcohol consumption habit, fasting blood glucose level, hemoglobin A1c level, diagnosis of diabetes, insulin use, blood pressure, body mass index were adjusted, the participants who consumed biscuit 1-11 times a year, 1-3 times a month, and more than once a week had a 139.8% (95% confidence interval, 1.003-5.734), 182.1% (95% confidence interval, 1.106-7.191), and 236.2% (95% confidence interval, 1.335-9.844) higher risk of diabetic retinopathy prevalence, respectively, compared with those who never ate biscuit. For male, non-Hispanic, and overweight (body mass index [greater than or equal to] 25 kg/m.sup.2) subgroups, the trend test demonstrated that the diabetic retinopathy prevalence significantly elevated with increased frequency of biscuit consumption (P.sub.trend = 0.021, 0.009, and 0.002, respectively). The interaction analysis suggested that no aforementioned confounders played an interactive role in the relationship between biscuit consumption and diabetic retinopathy prevalence. Conclusions The risk of diabetic retinopathy was positively associated with biscuit consumption. Moreover, for male, non-Hispanic, or overweight individuals, the risk of diabetic retinopathy significantly increased with the frequency of biscuit consumption. Keywords: Dietary, Biscuit, Diabetic retinopathy, The National Health and Nutrition Examination Survey, Binary logistic regression model.