Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 9; p. 1271
• Main Authors: Li, Hang-Ying, Yang, Wen-Qian, Zhou, Xin-Zhu, Shao, Fei, Shen, Tong, Guan, Hui-Ying, Zheng, Jie, Zhang, Li-Ming
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2022; MDPI
• Subjects: Acids; antibacterial activity; Antibacterial agents; Antibiotics; Antifungal activity; Antifungal agents; Antimicrobial agents; Bacteria; chemical structures; Drug resistance; Drug resistance in microorganisms; Fungi; Infectious diseases; Malaria; mechanism; Natural products; Review; Sesquiterpenes; Sesquiterpenoids; Staphylococcus infections; structure–activity relationship; China
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom12091271

Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that the efficacies of some antibacterial and antifungal agents have been weakened by the drug resistance of some bacteria and fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types and a wide range of bioactivities, are considered as good candidates to be antibacterial and antifungal agents. In the past decades, many sesquiterpenoids were isolated from plants and fungi that exhibited good antibacterial and antifungal activities. In this review, the names, source, structures, antibacterial and antifungal degrees, and mechanisms of sesquiterpenoids with antibacterial and antifungal activity from 2012 to 2022 are summarized, and the structure-activity relationship of these sesquiterpenoids against bacteria and fungi is also discussed.