Incidence of diabetes mellitus in Spain as results of the nation-wide cohort di@bet.es study

• Published in: Scientific reports Vol. 10; no. 1; p. 2765
• Main Authors: Rojo-Martínez, G., Valdés, S., Soriguer, F., Vendrell, J., Urrutia, I., Pérez, V., Ortega, E., Ocón, P., Montanya, E., Menéndez, E., Lago-Sampedro, A., González- Frutos, T., Gomis, R., Goday, A., García-Serrano, S., García-Escobar, E., Galán-García, J. L., Castell, C., Badía-Guillén, R., Aguilera-Venegas, G., Girbés, J., Gaztambide, S., Franch-Nadal, J., Delgado, E., Chaves, F. J., Castaño, L., Calle-Pascual, A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2020; Nature Publishing Group
• Subjects: 692/163/2743/137/773; 692/308/174; Adult; Age composition; Aged; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular Diseases - blood; Cardiovascular Diseases - complications; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - pathology; Cohort Studies; Cross-Sectional Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - pathology; Fasting; Female; Food consumption; Genetics; Glucose tolerance; Glucose Tolerance Test; Hip; Humanities and Social Sciences; Humans; Male; Middle Aged; multidisciplinary; Obesity; Obesity - blood; Obesity - complications; Obesity - epidemiology; Obesity - pathology; Physical activity; Population; Risk Factors; Science; Science (multidisciplinary); Spain - epidemiology; Spain
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-59643-7

Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the Spanish population. In total 5072 people older than 18 years,were randomly selected from all over Spain). Socio-demographic and clinical data, survey on habits (physical activity and food consumption) and weight, height, waist, hip and blood pressure were recorder. A fasting blood draw and an oral glucose tolerance test were performed. Determinations of serum glucose were made. In the follow-up the same variables were collected and HbA1c was determined. A total of 2408 subjects participated in the follow-up. In total, 154 people developed diabetes (6.4% cumulative incidence in 7.5 years of follow-up). The incidence of diabetes adjusted for the structure of age and sex of the Spanish population was 11.6 cases/1000 person-years (IC95% = 11.1–12.1). The incidence of known diabetes was 3.7 cases/1000 person-years (IC95% = 2.8–4.6). The main risk factors for developing diabetes were the presence of prediabetes in cross-sectional study, age, male sex, obesity, central obesity, increase in weight, and family history of diabetes. This work provides data about population-based incidence rates of diabetes and associated risk factors in a nation-wide cohort of Spanish population.