Renal sympathetic denervation for resistant hypertension: where do we stand after more than a decade

Despite the current availability of safe and efficient drugs for treating hypertension, a substantial number of patients are drug-resistant hypertensives. Aiming this condition, a relatively new approach named catheter-based renal denervation was developed. We have now a clinically relevant time win...

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Bibliographic Details
Published inBrazilian Journal of Nephrology Vol. 42; no. 1; pp. 67 - 76
Main Authors Fontes, Marco Antônio Peliky, Marzano, Lucas Alexandre Santos, Silva, Carina Cunha, Silva, Ana Cristina Simões E
Format Journal Article
LanguageEnglish
Published Brazil Sociedade Brasileira de Nefrologia 01.03.2020
Subjects
Adult
Blood Pressure
Denervation
Humans
Hypertension
Hypertension, Renal - physiopathology
Hypertension, Renal - surgery
Kidney - innervation
Kidney - physiopathology
Renal hypertension
Review
Risk
Sympathectomy
Sympathectomy - adverse effects
Sympathectomy - methods
Sympathetic nervous system
Sympathetic Nervous System - physiopathology
Sympathetic Nervous System - surgery
Treatment Outcome
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Summary:Despite the current availability of safe and efficient drugs for treating hypertension, a substantial number of patients are drug-resistant hypertensives. Aiming this condition, a relatively new approach named catheter-based renal denervation was developed. We have now a clinically relevant time window to review the efficacy of renal denervation for treating this form of hypertension. This short review addresses the physiological contribution of renal sympathetic nerves for blood pressure control and discusses the pros and cons of renal denervation procedure for the treatment of resistant hypertension.
ISSN:0101-2800
2175-8239
DOI:10.1590/2175-8239-JBN-2018-0213