Long-term central pathology and cognitive impairment are exacerbated in a mixed model of Alzheimer’s disease and type 2 diabetes

• Published in: Psychoneuroendocrinology Vol. 65; pp. 15 - 25
• Main Authors: Infante-Garcia, Carmen, Ramos-Rodriguez, Juan Jose, Galindo-Gonzalez, Lucia, Garcia-Alloza, Monica
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2016
• Subjects: Age Factors; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer Disease - psychology; Alzheimer’s disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - metabolism; Amyloid-beta; Animals; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Comorbidity; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Experimental - psychology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - psychology; Disease Models, Animal; Endocrinology & Metabolism; Haemorrhage; Mice; Mice, Inbred Strains; Microglia - metabolism; Microglia - pathology; Phosphorylation; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Psychiatry; Tau; tau Proteins - metabolism; Type 2 diabetes; Type 2 diabetes; Tau; Alzheimer’s disease; Haemorrhage; Amyloid-beta
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2015.12.001

Highlights • APP/PS1xdb/db mice show long-term cross-talk between metabolic and central deficits. • Brain atrophy in aged APP/PS1xdb/db mice is accompanied by reduced neuronal density. • Old APP/PS1xdb/db mice present increased axonal curvature and reduced spine density. • Spontaneous central bleeding is synergistically worsened in aged APP/PS1xdb/db mice. • Severe cognitive problems are observed in aged APP/PS1xdb/db mice.