An Electrochemical Sensor for the Detection of Albendazole Using Glassy Carbon Electrode Modified with Platinum-Palladium Nanocomposites

• Published in: Biosensors (Basel) Vol. 12; no. 11; p. 1026
• Main Authors: Suaifan, Ghadeer A. R. Y, Khanfar, Mohammad F, Shehadeh, Mayadah B, Alnajajrah, Asmaa, Abuhamdan, Raghad, Hasan, Sameer Ahmad
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 16.11.2022; MDPI
• Subjects: Acids; Albendazole; Analysis; Aqueous solutions; Bimetals; binary catalyst; Bioavailability; Biological properties; Biological samples; Carbon; Chemical sensors; Chickens; cyclic voltammetry; differential pulse voltammetry; Dosage; Dosage and administration; Drug dosages; Electrochemical analysis; Electrochemistry; electrode modification; Electrodes; Food industry; Food matrix; Glassy carbon; Metabolites; Methods; Nanocomposites; Nanoparticles; Oxidation; Palladium; Pharmaceuticals; Platinum; Quality control; Sensors; Soil contamination; Voltammetry; Jordan; United States > US
• ISSN: 2079-6374; 2079-6374
• DOI: 10.3390/bios12111026

An electroanalytical electrode for the detection of albendazole (ABZ) active ingredient in pharmaceutical dosage form and in contaminated animal-derived products was developed using a glassy carbon electrode modified with platinum-palladium nanoparticles. The electro-catalytic performance of the bimetallic-modified glassy carbon electrode was compared with its bare counterpart. Under optimized conditions, the modified electrode revealed two well-resolved anodic peak currents at 1.10 and 1.23 V using differential pulse voltammetry. Pure ABZ, as well as ABZ in spiked foods (milk and chicken), were detected with little interference from the food matrix. This electrode demonstrated high sensitivity and applicability, with a lower limit of detection of 0.08 µmol L−1 in aqueous solution and 10 µmol L−1 in the contaminated ground chicken and 100 µmol L−1 in the contaminated milk sample. The fabricated sensor is low in cost and appropriate for the estimation of albendazole in tablet dosage forms and biological samples, and so can act as a quality control tool in the pharmaceutical and food industry.