Psychosis and brain volume changes during the first five years of schizophrenia

Abstract The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An...

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Published inEuropean neuropsychopharmacology Vol. 19; no. 2; pp. 147 - 151
Main Authors Cahn, W, Rais, M, Stigter, F.P, van Haren, N.E.M, Caspers, E, Hulshoff Pol, H.E, Xu, Z, Schnack, H.G, Kahn, R.S
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2009
Subjects
Brain - pathology
Brain volumes
Cerebellum - pathology
Cerebral Ventricles - pathology
Disease Progression
Female
First-episode schizophrenia
Humans
Internal Medicine
Longitudinal
Longitudinal Studies
Magnetic Resonance Imaging
Male
Neuroimaging
Psychiatry
Psychosis
Schizophrenia - pathology
Schizophrenic Psychology
Young Adult
Psychosis
Neuroimaging
First-episode schizophrenia
Longitudinal
Brain volumes
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Summary:Abstract The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.
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ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2008.10.006