Dynamic modulation of theta–gamma coupling during rapid eye movement sleep

Abstract Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation; however, its spatial and temporal dynamics remains unclear. Here, we...

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Published inSleep (New York, N.Y.) Vol. 42; no. 12; p. 1
Main Authors Bandarabadi, Mojtaba, Boyce, Richard, Gutierrez Herrera, Carolina, Bassetti, Claudio L, Williams, Sylvain, Schindler, Kaspar, Adamantidis, Antoine
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.12.2019
Subjects
Animals
Brain
Eye movements
Gamma Rhythm - physiology
Hippocampus - physiology
Male
Memory Consolidation - physiology
Mice
Mice, Transgenic
Musical groups
Neurophysiology
Parietal Lobe - physiology
Sleep
Sleep, REM - physiology
Spatial Memory - physiology
Theta Rhythm - physiology
Wakefulness - physiology
active wake
hippocampus
theta–gamma coupling
optogenetics
REM sleep
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Summary:Abstract Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation; however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta–gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta–gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta–gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e. cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsz182